Approaches to synthesis of ([1,2,4]triazolo[1,5-c]quinazolin-2-yl)benzoic acids as potential anti-inflammators

Despite their high efficacy NSAIDs have significant side effects due to non-selective inhibition of COX-1 and COX-2. Due this, medical chemists still pay considerable attention design synthesis, in particular the creation hybrid molecules that combine structure a fragment with anti-inflammatory activity quinazoline heterocycle.
 The aim present study is develop methods for synthesis [1,2,4]triazolo[1,5-c]quinazolin-2-yl)benzoic acids as potential agents.
 Quinazolin-4(3H)-ylidene)hydrazides (hydrazones) benzenedicarboxylic acids, esters, products heterocyclization nucleophilic degradation were subjects study. synthesized compounds was confirmed by elemental analysis NMR spectroscopy. Anti-inflammatory studied model acute aseptic inflammation («carrageenan test») rats.
 Possibilities limitations esters via hetero­cyclization corresponding hydrazides hydrazones oxidative cyclization are shown. It found hydrolysis 4-[(1,2,4]triazolo[1,5-c]quinazolin-2-yl)benzoic acid not preparative method target hydrolytic cleavage pyrimidine cycle. Compounds 3, 4 6 moderate been identified, which can be used further structural modification.
 Conclusions. quinazolin-4(3H)-ylidene)hydrazides under conditions form esters. carriers promising research.